Antibody Discovery Platform
Built on a Saccharomyces cerevisiae eukaryotic display system, antibody fragments are presented on the yeast cell surface for high-throughput screening by flow cytometric sorting.
A Saccharomyces cerevisiae eukaryotic display system presents antibody fragments on the cell surface for high-throughput screening by flow cytometry.
Its mammalian-like folding machinery recovers correctly folded, highly stable antibody molecules, making it the core tool for affinity maturation and developability optimisation.
Flow cytometry's quantitative sorting lets selection pressure be tuned by binding signal, and selected clones can then be moved into a mammalian system and produced as full antibodies.
Enquire now →
Four stages. Antibody fragments are displayed on the surface of Saccharomyces cerevisiae and sorted quantitatively by flow cytometry — well suited to affinity maturation and developability optimisation.
Antibody fragment genes are cloned into the display vector and transformed into a library
Expression is induced and the fragments displayed on the yeast cell surface
Flow cytometry sorts target clones quantitatively by binding signal
Selected clones are sequenced, with conformation and stability verified
Its mammalian-like folding machinery lets yeast display recover correctly folded, highly stable antibody molecules — the core tool for affinity maturation and developability optimisation — while flow cytometry's quantitative sorting allows selection pressure to be tuned precisely.
Share the intended application and what you already have in hand. A scientist — not a sales rep — will scope feasibility, suggest the right route and send a quote, usually within one business day.
