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ManualCOAMSDSTrophoblast glycoprotein (TPBG), also known as 5T4, is a carcinoembryonic type I transmembrane glycoprotein that is specifically expressed in the placental trophoblast during embryonic development, where it participates in implantation and embryogenesis, while exhibiting only minimal expression in normal adult tissues. This target is highly expressed across multiple solid tumor types, including lung, gastric, and ovarian cancers, where it mediates tumor invasion and metastasis, and has therefore emerged as a promising therapeutic target for antibody-drug conjugates (ADCs) and cancer vaccines, as well as an unfavorable prognostic biomarker.
| Synonyms | TPBG, 5T4, M6P1, 5T4AG, WAIF1, 5T4 oncofetal antigen, Trophoblast glycoprotein, 5T4 oncofetal trophoblast glycoprotein |
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| Protein Construction ＆ Source | ·Recombinant Human (Uniprot: Q13641-1) TBPG Protein is expressed from CHO cells with Avi-His tag at the C-Terminus. It contains AA Ser 32 - Ser 355.·The protein has a predicted MW of 38.9 kDa. The protein migrates as 50-70 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | ＞90% as determined by SEC-HPLC. |
| Concentration ＆ Formulation | ·3.56 mg/mL·Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| Transportation ＆ Storage | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | Trophoblast glycoprotein (TPBG), also known as 5T4, is a carcinoembryonic type I transmembrane glycoprotein that is specifically expressed in the placental trophoblast during embryonic development, where it participates in implantation and embryogenesis, while exhibiting only minimal expression in normal adult tissues. This target is highly expressed across multiple solid tumor types, including lung, gastric, and ovarian cancers, where it mediates tumor invasion and metastasis, and has therefore emerged as a promising therapeutic target for antibody-drug conjugates (ADCs) and cancer vaccines, as well as an unfavorable prognostic biomarker. |
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