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ManualCOAMSDSSIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder.
| Synonyms | CD327, CD33L, CD33L1, OBBP1, OB-BP1, CDw327 |
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| Protein Construction ＆ Source | •(Uniprot: O43699-3)Recombinant Human SIGLEC6 Protein is expressed from HEK293 cells with hFc(IgG1) tag at the C-terminus. It contains AA Gln 27 - Ser 331. •The protein has a predicted MW of 88.6 kDa. The protein has a predicted MW of 59.8 kDa. The protein migrates as 70-85 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 90 % as determined by SDS-PAGE. |
| Concentration ＆ Formulation | •4.74 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| Transportation ＆ Storage | This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.•Protein solution can be stored at 2-8°C for 2-7 days.•Samples are stable for 3 months from date of receipt at -20℃ /-80℃.•Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | SIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder. |
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