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ManualCOAMSDS
CD38 (ADP-ribosyl cyclase 1) is an ADP-ribosyl cyclase family protein highly expressed in multiple normal tissues, lymphoma and neuroblastoma. This multifunctional ectoenzyme mediates cyclic ADP-ribose (cADPR) metabolism from NAD+ to ADP-ribose, governing intracellular Ca2+ homeostasis. CD38 dysfunction causes immune and metabolic defects alongside behavioral changes. As a cell activation marker, it is associated with HIV, hematologic and solid tumors, type 2 diabetes and bone metabolism, and serves as a prognostic biomarker for leukemia.
| Synonyms | CD38, T10, cADPr hydrolase 1 |
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| Protein Construction ＆ Source | ·Recombinant Human(Uniprot: P28907-1) CD38 Protein is expressed from HEK293 cells with Alpaca Fc tag at the C-terminus.It contains AA Val 43- Ile 300.·The protein has a predicted MW of 56.6 kDa. The protein migrates as 35-45 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 95% as determined by SDS-PAGE. |
| Concentration ＆ Formulation | ·5.44 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| Transportation ＆ Storage | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | CD38 (ADP-ribosyl cyclase 1) is an ADP-ribosyl cyclase family protein highly expressed in multiple normal tissues, lymphoma and neuroblastoma. This multifunctional ectoenzyme mediates cyclic ADP-ribose (cADPR) metabolism from NAD+ to ADP-ribose, governing intracellular Ca2+ homeostasis. CD38 dysfunction causes immune and metabolic defects alongside behavioral changes. As a cell activation marker, it is associated with HIV, hematologic and solid tumors, type 2 diabetes and bone metabolism, and serves as a prognostic biomarker for leukemia. |
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