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ManualCOAMSDS
4-1BB (CD137/TNFRSF9/ILA) is a co-stimulatory receptor of the TNF receptor superfamily. Expressed mainly on activated T cells with higher levels in CD8+ than CD4+ T cells, it is also detected in dendritic cells, NK cells, granulocytes and vascular wall cells under inflammation. CD137 crosslinking promotes T-cell proliferation, IL-2 secretion, survival and cytolytic function. The 4-1BB/4-1BBL pathway boosts secondary CTL responses against viruses and anti-tumor immunity in mice, although it also enhances TCR/CD3-triggered activation-induced T-cell apoptosis. CD137 interacts with TRAF2 for downstream signaling, making it a promising target for human cancer immunotherapy
| Synonyms | TNFRSF9, 4-1BB, CD137, CDw137, ILA |
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| Protein Construction ＆ Source | ·Recombinant Human(Uniprot: Q07011-1) CD137 Protein is expressed from HEK293 cells with Avi-His tag at the C-terminus.It contains AA Leu 24 - Gln 186.·The protein has a predicted MW of 20.8 kDa. The protein migrates as 30-40 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 90% as determined by SDS-PAGE. |
| Concentration ＆ Formulation | ·1.54 mg/mL ·Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| Transportation ＆ Storage | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | 4-1BB (CD137/TNFRSF9/ILA) is a co-stimulatory receptor of the TNF receptor superfamily. Expressed mainly on activated T cells with higher levels in CD8+ than CD4+ T cells, it is also detected in dendritic cells, NK cells, granulocytes and vascular wall cells under inflammation. CD137 crosslinking promotes T-cell proliferation, IL-2 secretion, survival and cytolytic function. The 4-1BB/4-1BBL pathway boosts secondary CTL responses against viruses and anti-tumor immunity in mice, although it also enhances TCR/CD3-triggered activation-induced T-cell apoptosis. CD137 interacts with TRAF2 for downstream signaling, making it a promising target for human cancer immunotherapy |
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