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ManualCOAMSDSEpCAM is a pan-epithelial differentiation antigen recognized by the 17-1A monoclonal antibody, widely expressed across nearly all carcinoma types. Its physiological functions remain incompletely defined, yet it tightly interacts with the cadherin-catenin complex to modulate the core WNT pathway governing intracellular signaling and epithelial polarity. Highly abundant in most epithelial malignancies, EpCAM serves as a validated tumor biomarker and a promising target for molecular therapy. Research further confirms EpCAM engages PI3K-mediated crosstalk with N-cadherin to disrupt epithelial cadherin adhesion assemblies; additionally, it has emerged as a vital prognostic indicator for breast cancer.
| Synonyms | EpCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK-1 |
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| Protein Construction ＆ Source | •(Uniprot: P16422-1) Recombinant Human EpCAM Protein is expressed from HEK293 cells with hFc (IgG1) tag at the C-terminus. It contains AA Gln 24 - Lys 265. •The protein has a predicted MW of 53.5 kDa. The protein migrates as 55-70 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 89% as determined by SEC-HPLC. |
| Concentration ＆ Formulation | •4.75 mg/mL•Filtered through a 0.22 μm filter, stored in 20mM Sodium Citrate, 200mM Arg-HCl, 1x PBS, pH 7.4. |
| Transportation ＆ Storage | This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.•Protein solution can be stored at 2-8°C for 2-7 days.•Samples are stable for 3 months from date of receipt at -20℃ /-80℃.•Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | EpCAM is a pan-epithelial differentiation antigen recognized by the 17-1A monoclonal antibody, widely expressed across nearly all carcinoma types. Its physiological functions remain incompletely defined, yet it tightly interacts with the cadherin-catenin complex to modulate the core WNT pathway governing intracellular signaling and epithelial polarity. Highly abundant in most epithelial malignancies, EpCAM serves as a validated tumor biomarker and a promising target for molecular therapy. Research further confirms EpCAM engages PI3K-mediated crosstalk with N-cadherin to disrupt epithelial cadherin adhesion assemblies; additionally, it has emerged as a vital prognostic indicator for breast cancer. |
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For research use only. Not for use in diagnostic or therapeutic procedures.
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