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ManualCOAMSDSInterleukin 22 (IL22, alias Zcyto18/IL TIF) is a member of the IL 10 superfamily. Produced by activated dendritic and T cells, it mediates innate immunity against bacteria mainly in respiratory and intestinal epithelia. IL22 signals via a membrane receptor complex (IL 22R1/IL 10R2), with its activity modulated by soluble IL 22BP. Like IL 10, IL22 supports survival of hepatocytes and epithelial cells.
| Synonyms | IL-22, IL-TIF, ZCYTO18 |
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| Protein Construction ＆ Source | •(Uniprot: Q9GZX6-1) Recombinant Human IL22 Protein is expressed from HEK293 cells with His tag at the C-terminus. It contains AA Met 1-IIe 179. •The protein has a predicted MW of 20.6 kDa. The protein migrates as 25-40 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 90% as determined by SDS-PAGE. |
| Concentration ＆ Formulation | •1.95 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| Transportation ＆ Storage | This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.•Protein solution can be stored at 2-8°C for 2-7 days.•Samples are stable for 3 months from date of receipt at -20℃ /-80℃.•Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | Interleukin 22 (IL22, alias Zcyto18/IL TIF) is a member of the IL 10 superfamily. Produced by activated dendritic and T cells, it mediates innate immunity against bacteria mainly in respiratory and intestinal epithelia. IL22 signals via a membrane receptor complex (IL 22R1/IL 10R2), with its activity modulated by soluble IL 22BP. Like IL 10, IL22 supports survival of hepatocytes and epithelial cells. |
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