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ManualCOAMSDS
SIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder.
| Synonyms | SIGLEC6, CD327, CD33L, CD33L1, OBBP1, OB-BP1, CDw327 |
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| Protein Construction ＆ Source | ·Recombinant Human(Uniprot: O43699-3) SIGLEC6 Protein is expressed from HEK293 cells with Alpaca Fc tag at the C-terminus.It contains AA Gln 27- Val 331.·The protein has a predicted MW of 60.4 kDa. The protein migrates as 70-85 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 95% as determined by SDS-PAGE. |
| Concentration ＆ Formulation | ·1.21 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| Transportation ＆ Storage | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | SIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder. |
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