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ManualCOAMSDS
Interleukin- 22 (IL22, alias Zcyto18/IL- TIF) is a member of the IL- 10 superfamily. Produced by activated dendritic and T cells, it mediates innate immunity against bacteria mainly in respiratory and intestinal epithelia. IL22 signals via a membrane receptor complex (IL- 22R1/IL- 10R2), with its activity modulated by soluble IL- 22BP. Like IL- 10, IL22 supports survival of hepatocytes and epithelial cells
| Synonyms | IL-22, IL-TIF, ZCYTO18 |
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| Protein Construction ＆ Source | ·Recombinant Human(Uniprot: Q9GZX6-1) IL22 Protein is expressed from HEK293 cells with hFc(IgG1) tag at the C-terminus.It contains AA Ala 34-IIe 179.·The protein has a predicted MW of 42.8 kDa. The protein migrates as 45-55 kDa when calibrated against under reducing (R condition (SDS-PAGE) due to glycosylation. |
| Endotoxin | < 0.1 EU per ug as determined by the LAL method. |
| Purity | > 95% as determined by SDS-PAGE. |
| Concentration ＆ Formulation | ·2.06 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS, pH 7.4. |
| Transportation ＆ Storage | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Target background | Interleukin- 22 (IL22, alias Zcyto18/IL- TIF) is a member of the IL- 10 superfamily. Produced by activated dendritic and T cells, it mediates innate immunity against bacteria mainly in respiratory and intestinal epithelia. IL22 signals via a membrane receptor complex (IL- 22R1/IL- 10R2), with its activity modulated by soluble IL- 22BP. Like IL- 10, IL22 supports survival of hepatocytes and epithelial cells |
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